Granulomatosis with polyangiitis (Wegener’s granulomatosis)

A 60-year-old woman with a confirmed diagnosis of granulomatosis with polyangiitis (GPA) presents with worsening nasal congestion, hemoptysis, and new onset of red, painful nodules on her legs. Her current medications include low-dose prednisone. Laboratory tests show elevated inflammatory markers and worsening renal function.

What is the most appropriate next step in the management of this patient?

A 48-year-old man with granulomatosis with polyangiitis (GPA) presents with increasing shortness of breath and chest pain. He has a history of hemoptysis and is currently on maintenance therapy with azathioprine and low-dose prednisone. On examination, he has decreased breath sounds and dullness to percussion on the right side. A chest X-ray shows a large pleural effusion.

What is the most likely complication associated with his current symptoms?

A 50-year-old man with granulomatosis with polyangiitis has been treated with corticosteroids and cyclophosphamide. His symptoms have resolved, and his renal function has stabilized.

What is the most likely prognosis for this patient following successful treatment?

A 40-year-old woman presents with a 2-week history of cough with blood-tinged sputum, shortness of breath, and hematuria. Physical examination reveals pallor and bilateral lung crackles.

Which of the following is a clinical feature commonly associated with granulomatosis with polyangiitis?

A 40-year-old man presents with asthma, sinusitis, peripheral eosinophilia, and transient pulmonary infiltrates. He also reports a history of fleeting joint pains and numbness in his hands and feet.

What is the most likely diagnosis?

A 50-year-old man presents with a 3-month history of fatigue, weight loss, nasal congestion, and recurrent sinusitis. He also reports hemoptysis and shortness of breath over the past week. On examination, he has a saddle-nose deformity and bilateral crackles on lung auscultation. Laboratory tests show elevated inflammatory markers, and a urinalysis reveals hematuria and proteinuria.

What is the most appropriate initial test to support the diagnosis of granulomatosis with polyangiitis (GPA)?