Angiodysplasia Accordion Q&A Notes
Angiodysplasia Active Recall Accordion Q&A Revision Notes
(Question and Answer Active Recall Accordion Notes – please click the arrow to display the answer to the revision questions)
Definition of Angiodysplasia
• Abnormal fragile blood vessels (vascular deformity) in the gastrointestinal tract frequently found in the colon
• Higher risk of bleeding and iron deficiency anemia.
• There is a debated connection between Angiodysplasia and aortic stenosis.
• Commonly observed in elderly individuals.
Aetiology of Angiodysplasia
• The exact cause is not well understood.
• Age-related degenerative changes in blood vessels.
• Blood vessel fragility is believed to contribute.
Risk Factors for Angiodysplasia
• Advanced age
• Chronic kidney disease
• Underlying conditions: Von Willebrand disease
Pathophysiology of Angiodysplasia
• Dilation and tortuosity of blood vessels in the gastrointestinal mucosa
• Formation of fragile vascular lesions
Differential Diagnosis of Angiodysplasia
• Diverticulosis
• Colorectal cancer
• Inflammatory bowel disease
• Arteriovenous malformations
Epidemiology of Angiodysplasia (UK)
• The prevalence of Angiodysplasia rises with age.
• Individuals over 60 years old have a higher incidence.
Clinical Presentation of Angiodysplasia
• Intermittent painless bleeding.
• Bright red blood in stool
• Melena (black tarry stools)
Investigations for Angiodysplasia
• Colonoscopy: Investigates lower gastrointestinal bleeding, allows direct visualization of the colon and rectum, helps identify the source of bleeding
• Oesophagogastroduodenoscopy (OGD): Evaluates upper gastrointestinal bleeding, involves examining the esophagus, stomach, and duodenum, aids in locating the bleeding site
• Mesenteric angiography: Performed during acute bleeding, helps identify the source within the mesenteric vessels
• An interventional radiology technique for assessment and potential treatment
• Essential for identifying the location and cause of gastrointestinal bleeding
• Enable appropriate treatment and management decisions
Management of Angiodysplasia
• Thermal coagulation
• Argon plasma coagulation: Used to seal bleeding vessels
• Surgical Intervention: Reserved for severe cases
• Antifibrinolytics: e.g., Tranexamic acid
• Oestrogens
Prognosis of Angiodysplasia
• Generally favorable
Complications of Angiodysplasia
• Recurrent bleeding
• Anemia
• Rarely severe gastrointestinal hemorrhage: May necessitate blood transfusion; surgical intervention might be required