Haemophilia A
Introduction to Haemophilia A
Welcome to the Haemophilia A subsection of the Haematology for the MSRA course.
This section is designed to provide comprehensive and structured learning materials to help you understand and master the topic of Haemophilia A for the MSRA.
Resources for Haemophilia A:
- Haemophilia A Revision Notes for MSRA: Detailed and concise notes covering causes, symptoms, diagnosis, and treatment based on UK NICE guidelines. Use these notes to get a thorough understanding of the condition.
- Haemophilia A Flashcards for MSRA: Interactive flashcards to help you retain key facts and concepts related to haemophilia A. Perfect for quick revision sessions and reinforcing knowledge.
- Haemophilia A Accordion Q&A Notes for the MSRA: A question-and-answer style resource designed to enhance active learning and test your understanding. Ideal for quick coverage of weak areas.
- Haemophilia A Rapid Fire Quiz for MSRA: A fast-paced quiz to evaluate your recall and understanding of haemophilia A. Use it to assess your progress and readiness for more advanced material.
We encourage you to use these resources as part of your revision plan, and explore related topics within the Haematology for the MSRA course.
Key Points about Haemophilia A:
- Definition: Haemophilia A is a genetic bleeding disorder caused by a deficiency of factor VIII, leading to problems with blood clotting and an increased risk of bleeding.
- Causes:
- X-linked recessive inheritance pattern, primarily affecting males.
- Mutations in the F8 gene that encodes factor VIII.
- Symptoms:
- Prolonged bleeding from cuts or injuries.
- Spontaneous joint and muscle bleeds.
- Excessive bruising and prolonged bleeding after surgery or dental work.
- Diagnosis:
- Blood tests showing low levels of factor VIII activity.
- Prolonged activated partial thromboplastin time (aPTT).
- Genetic testing to confirm mutations in the F8 gene.
- Management:
- Regular prophylactic infusions of factor VIII concentrate to prevent bleeding episodes.
- Desmopressin (DDAVP) for mild cases to stimulate the release of stored factor VIII.
- Education and lifestyle modifications to reduce the risk of injury and bleeding.
- Complications:
- Joint damage (haemarthrosis) due to recurrent bleeding into joints.
- Development of inhibitors (antibodies) against factor VIII treatment.
- Increased risk of serious bleeding, including intracranial hemorrhages.
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