Chronic Myeloid Leukaemia
Introduction to Chronic Myeloid Leukaemia
Welcome to the Chronic Myeloid Leukaemia subsection of the Haematology for the MSRA course.
This section is designed to provide comprehensive and structured learning materials to help you understand and master the topic of Chronic Myeloid Leukaemia for the MSRA.
In this subsection, you will find the following resources to aid your revision:
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Chronic Myeloid Leukaemia Revision Notes for MSRA:
Detailed and concise traditional revision notes covering all essential aspects of Chronic Myeloid Leukaemia, including its causes, symptoms, diagnosis, and treatment. These notes are based on UK NICE guidelines and displayed in an easy-to-recall table format. -
Chronic Myeloid Leukaemia Flashcards for MSRA:
Interactive flashcards to help you memorise key facts and concepts about Chronic Myeloid Leukaemia. These are perfect for quick reviews and reinforcing your knowledge. -
Chronic Myeloid Leukaemia Accordion Q&A Notes for MSRA:
A unique feature where you can test your understanding of Chronic Myeloid Leukaemia with question-and-answer style revision notes. This format helps with active learning and retention of important information. -
Chronic Myeloid Leukaemia Rapid Fire Quiz for MSRA:
A short quiz to test your knowledge and recall of Chronic Myeloid Leukaemia-related concepts. This is an excellent way to assess your progress and identify areas that need further review.
Key Points about Chronic Myeloid Leukaemia:
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Definition:
Chronic Myeloid Leukaemia (CML) is a clonal myeloproliferative disorder of the white blood cells, characterised by uncontrolled proliferation of mature and maturing granulocytes. It is strongly associated with the Philadelphia chromosome. -
Causes:
Caused by a reciprocal translocation between chromosomes 9 and 22, producing the BCR-ABL fusion gene, which encodes an abnormal tyrosine kinase. -
Symptoms:
Patients may present with fatigue, weight loss, night sweats, splenomegaly, and early satiety. Some are asymptomatic and diagnosed incidentally via a raised white cell count. -
Diagnosis:
Diagnosis is confirmed by detecting the Philadelphia chromosome via cytogenetics or BCR-ABL fusion gene by PCR. Blood tests typically show marked leucocytosis, basophilia, and eosinophilia. -
Management:
First-line treatment is with tyrosine kinase inhibitors (TKIs) such as imatinib. Treatment response is monitored with serial BCR-ABL levels. Allogeneic stem cell transplantation may be considered in refractory cases. -
Complications:
CML may progress to accelerated phase or blast crisis, resembling acute leukaemia. Long-term complications include drug resistance and secondary cytopenias.
We hope you find these resources helpful and engaging as you prepare for the MSRA. Make sure to explore other related topics in Haematology for the MSRA.
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